![]() ![]() Examples include autoimmune disease (e.g., multiple sclerosis), metabolic diseases (e.g., diabetic neuropathy), infection (e.g., shingles and the sequel, postherpetic neuralgia), vascular disease (stroke), trauma, and cancer. There are a number of diseases associated with neuropathic pain. Neuropathic pain is defined as pain resulting from damage or dysfunction of the peripheral nerves and more broadly, as a result of injury or disease of the somatosensory system. SCS reduced glial activation at the level of the spinal cord suggesting reduction in central excitability. In conclusion, 4Hz and 60Hz SCS for a 6h at 90% MT were the most effective parameters for reducing hyperalgesia, suggesting parameters of stimulation are important for effectiveness of SCS. SCS decreased glial activation (GFAP, MCP-1 and OX-42) in the spinal cord dorsal horn when compared to sham. For intensity, 90% MT was greater than 75% MT and both were greater than 50% MT or sham SCS. For duration, 6h of SCS showed a greater reduction in MWT when compared to 30 min. For frequency, 4Hz or 60Hz SCS reversed the MWT when compared to sham SCS. All rats showed a decrease in MWT 2 weeks after nerve injury and an increase in glial activation. Seperate groups of animals were tested for glial immunoreactivity after 4 days of 6h SCS. Animals were tested for mechanical withdrawal threshold (MWT) of the paw before and 2 weeks after SNI, before and after SCS daily for 4 days, and for 9 days after SCS. An epidural SCS lead was implanted in the upper lumbar spinal cord. To elucidate potential mechanisms modulated by SCS, we examined immunoreactivity glial markers in the spinal cord after SCS). We examined parameters of SCS in rats with spared nerve injury by modulating frequency (4Hz vs. Spinal cord stimulation (SCS) is used to manage chronic intractable neuropathic pain. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |